Longevity
"Death is laying there with dirt in your face and holding your breath forever."
– Burt Reynolds
Last week we promised to discuss melatonin and DHEA.
A recent study suggests that melatonin may be key to reducing the incidence of cancer. The study suggests that children who sleep with a light on have reduced melatonin production and an increased incidence of cancers such as leukemia. Given the marked decline in melatonin production in adults as they age and the coincident increased incidence of cancer in older adults, there may be something to this study.
What is melatonin? It is a chemical secreted by the pineal gland. The pineal gland is a very small gland in the skull which produces two chemicals: seratonin and melatonin. When there is light on the body and especially on the eyes, the pineal gland produces seratonin which is a key neurotransmitter associated with energetic activity, movement, and positive emotions. When there is an absence of light for a period of thirty minutes or more, the pineal gland secretes melatonin. Melatonin is associated with sleep, lassitude, and feeling tired.
Deep sound sleep is very important for the brain and body. Many aspects of physical, emotional, and even spiritual regeneration seem to be associated with deep sleep. Melatonin acts to encourage deep sleep.
Unfortunately, as you age, the pineal gland produces less and less melatonin. It may also produce less seratonin, although there are other sources of seratonin.
Melatonin may also have important functions in sexuality. Tumors in the pineal gland seem to be associated with precocious sexual development in boys, for example.
Fortunately, melatonin may be supplemented. Artificial melatonin as n-Acetyl-5-Methoxytryptamine is available in various doses. The benefits seem to be available from doses as tiny as 300 micrograms or about three tenths of a milligram.
(As the name would seem to imply, some related effects may be found in foods or supplements providing the amino acid tryptophan. Dietary deficiency of tryptophan is associated with the disease pellagra. Niacin or nicotinic acid, another important brain chemical, is produced from tryptophan.)
Researchers at Israel's Hebrew University in Jerusalem report that melatonin is neuroprotective. Traumatic brain injury leads to massive production of reactive oxygen which in turn increases brain damage. Melatonin enhances brain anti-oxidants, incuding Vitamin C. In a study of mice given closed head injury, melatonin facilitated recovery and caused a twofold decrease in brain lesion size.
Among its other uses, a melatonin supplement may b useful in controlling the effects of jet lag. By taking melatonin and proceeding to a dark bedroom, a person may adjust his sleep cycle to the new time zone where he finds himself. Having deep sleep on the schedule of the new time zone seems to be sufficient to re-adjust the body clock.
A recent study indicates a possible link between repeated bedtime use of melatonin and reduced nocturnal blood pressure.
If the studies showing a role for melatonin in limiting susceptibility to cancer prove out, the regenerative qualities of a good night's sleep may be much greater than once believed. If nothing else, melatonin supplements often help older people sleep through the night or return to sleep after waking up to relieve bladders. Having good rest seems to help in better feelings during the day, so the quality of life should be enhanced. As for longevity, there is an old saying that you sleep a third of your life. If you have difficulty sleeping, perhaps your lifespan would be reduced.
DHEA is another chemical secreted by one of your glands. In this case, it is di-hydro-epi-androsterone, sometimes abbreviated as DHEAS, and is secreted by your adrenal glands. As with melatonin, the adrenal glands seem to produce less DHEA as you grow older.
(As the name suggests, DHEA is a type of steroid. It is not recommended for persons under 18 years of age.)
Although DHEA is the most abundant circulating hormone in the human body, production peaks at age 25 and drops dramatically each year thereafter. By the time most people are age 70, their levels of DHEA have declined by over 80%. This decline may lead to hormonal imbalances which can affect the quality of life.
To achieve the levels of DHEA found in a 25-year-old, men would normally take 50 milligrams per day. Women usually need only 15 to 25 milligrams per day.
Among other benefits, DHEA seems to help women with improved skin appearance. DHEA exerts specific anabolic effects that result in youthful cell renewal. It has also been shown to have an oxygen-sparing effect on skin cells, helping to protect them from thermal injury. DHEA appears to improve the vascular structure of the skin (capillaries) thereby protecting cells from destruction due to oxidative damage).
An article published in Science 2 Aug 2002 indicates a correlation between blood DHEA level and longevity.
DHEA is a natural, intermediate steroid hormone produced in our body by the adrenal glands. DHEA is the mother of (not quite all) hormones, or pro-hormone because DHEA is further converted to generate 50 other essential hormones. For example, DHEA is converted to androgens (male hormones) or estrogens (female hormones) in the cells.
There is some evidence that DHEA supplements may exacerbate difficulties in patients with prostate cancer and some other cancers. However, these studies remain controversial.
Other studies suggest DHEA can prevent cancer, atherosclerosis, diabetes, Alzheimer's, multiple sclerosis, obesity and Parkinson's disease and enhance immune functions. In controlled tests DHEA has increased the life span of laboratory animals by 50%. Many longevity researchers believe that its disappearance from the body is one of the main reasons people age.
If you find these topics interesting, we recommend you consider a subscription to Life Extension News from the Life Extension Foundation lef.org or the Life Enhancement newsletter from life-enhancement.com. Both organizations also sell quality supplements and work in the fight against FDA foolishness.
As always, none of the statements we've made have been approved by your doctor, the FDA, the government, the banking cartel, nor the military industrial complex. If that sort of thing matters to you, The Indomitus Report may not be the right newsletter for you.